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As a result of previous Thyrotropin Releasing Hormone research findings, we set out to learn more about the effects, dosage, and timing of administration of TRH according to its circadian cyclicity. We want to examine its effects on organs, tissues, and aging-related metabolic and hormonal markers following short-term, acute, or chronic oral administration.
In addition, we were interested in confirming its anti-aging effects on the gonadal-reproductive and kidney-urinary systems. These findings show that administration of TRH to old, aging mice, either acutely for a short period or chronically over a long period, causes favorable modifications and quick correction to more juvenile levels of most normal age-related hormonal and metabolic aberrations.
Remarkably, this peptide may preserve the testicular function in aged mice with a 4-month course of oral TRH therapy. The active proliferation and creation of mature spermatogonia and intense spermatogenesis in the follicles suggest that TRH ingested in the diet leads to the maintenance and reconstitution of the testes’ structure and function, as shown by the significant rise in testes’ weight. Treatment with TRH for 4 months prevents the tubuli and glomeruli from being infiltrated by amyloid and hyalin, which is common in aged mice. Specifically, the glomeruli of untreated mice with filtration capacity loss are infiltrated by large deposits of amyloid and hyalin material. In contrast, in TRH-treated animals, these deposits are much less noticeable. Untreated mice also show significant hyaline degeneration in their tubular vasculature.
The results of these trials with parenteral and oral administration of TRH demonstrate the outstanding anti-aging benefits of this neuropeptide. We are again faced with an anti-aging medication that, like melatonin, has a wide variety of effects, all of which must be intrinsically tied to its essential role in controlling metabolism and hormones.
Although it is more accurately called a “Thyrotropin-releasing hormone,” the name “Thyroid releasing hormone” (TRH) is a very terrible and inaccurate description of what this hormone does. This little molecule, which consists of only three amino acids, is present in all living things, from single-celled algae to multicellular mammals.
Its highest concentration in the human body is found in the beta cells of the pancreas, the pineal gland, and the anterior hypothalamus. No harmful or unpleasant effects have ever been noted, even when given intravenously at very high concentrations. Hundreds of articles have shown its favorable benefits since its discovery in the 1950s by Nobel Laureate Roger Guillemin. Although TRH has shown promise in the clinic, its short half-life has limited its use because of how quickly it is broken down in the digestive tract. Therefore, subcutaneous dosing has been helpful.
How does TRH function? Dr. Walter Pierpaoli released his first relevant study in 1989–1990, detailing the astounding range of effects of TRH in the restoration of the thymus, the holy grail gland for the immune system, which usually diminishes with age, and its anti-viral actions against a fatal virus. However, an increase in thyroid hormone is not solely responsible for all TRH’s effects. More recent studies have also shown that TRH may slow the aging process.
Recent work by Dr. Pierpaoli using various mouse obesity models demonstrates that TRH may directly act on the hormones governing fat storage to reverse and diminish aging-related adiposity and rectify aging-related hormonal changes. He has also seen that TRH causes a quick drop in leptin levels, a rapid mobilization of blood triglycerides, and an equally quick weight reduction.
According to Dr. Pierpaoli, TRH might be an essential factor in the hormonal control of body weight and fat reserves. As the body’s ability to regulate its weight naturally declines with age, this system becomes more critical. Dr. Pierpaoli presented convincing data for the wide range of anti-aging effects of TRH at the Stromboli Conference on Aging and Cancer. In addition to restoring all parameters to youthful levels, Dr. Pierpaoli also reversed testicular atrophy and restored spermatozoa production and maturation. He restored kidney function and preserved glomerular filtration and tubular function by eliminating hyalin and amyloid infiltration, two hallmarks of kidney degeneration.
In conclusion, the study of Dr. Pierpaoli reveals that TRH is a master hormone responsible for readjusting various imbalances throughout the body, not simply thyroid hormones (its principal recognized job). For example, in his animal trials, TRH supplements have encouraged elderly animals to re-establish spermatogenesis, end kidney dysfunction, replace faulty pancreatic enzymes, use it as a cancer preventative and treatment, and reduce the body fat percentage and weight in only two to three months. In 2011, Dr. Pierpaoli planned to publish a book detailing his patients and outcomes and disclosing the available research on this extraordinary chemical. If you are looking for this compound, you can buy Thyrotropin peptide online
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